The Joint FAO/WHO Expert Committee on Food Additives (JECFA, 1990) assessed the compound together with six other cellulose derivatives and allocated a group acceptable daily intake (ADI) of ‘not specified’. The Scientific Committee for Food (SCF, 1994, 1999) who assessed five closely related cellulose derivatives, also allocated a group ADI of ‘not specified’. The most recent evaluation of cellulose and cellulose derivatives, including HPMC for their use as food additives was done in 2018 by the EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) (EFSA ANS Panel, 2018), which concluded that there was no need to set a numerical ADI.
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