hydroxypropyl methyl cellulose cas number

An Overview of Hydroxypropyl Methyl Cellulose (HPMC)

Hydroxypropyl Methyl Cellulose (HPMC) is a non-ionic cellulose derivative that has gained significant attention across various industries due to its unique properties and versatility. With a CAS number of 9004-65-3, HPMC is widely utilized in pharmaceuticals, food, and construction, among other fields. This article provides an overview of HPMC, its chemical properties, applications, and safety considerations.

Chemical Structure and Properties

HPMC is derived from cellulose, the primary structural component of plant cell walls. Its chemical structure includes hydroxypropyl and methoxy groups, which modify the cellulose molecule to provide it with distinctive properties. The degree of substitution of hydroxypropyl and methoxy groups can be adjusted, resulting in various grades of HPMC, each with specific characteristics, such as viscosity and solubility.

One of the key properties of HPMC is its ability to form a gel-like consistency in the presence of water. This property makes it an excellent thickening agent and stabilizer. HPMC is odorless, tasteless, and soluble in both cold and hot water, making it suitable for numerous applications. Its film-forming capability also adds to its versatility, allowing it to be utilized as a coating agent.

Applications in Various Industries

1. Pharmaceutical Industry HPMC is extensively used in the pharmaceutical industry as a binder in tablets and as a coating agent for controlled-release formulations. Its gel-forming ability is particularly valuable in creating sustained-release medications, where the release rate of the drug needs to be controlled over an extended period. Additionally, HPMC is often utilized in the formulation of eye drops and other topical preparations due to its excellent tolerance and viscosity.

2. Food Industry In the food sector, HPMC serves as a food additive, where it is employed as a thickener, emulsifier, and stabilizer. It enhances the texture of food products, contributes to moisture retention in baked goods, and improves the overall mouthfeel of sauces and dressings. HPMC is also used in gluten-free products, providing structure and elasticity that impart a desirable consistency to these alternatives.

3. Construction Industry HPMC finds significant usage in the construction industry, particularly in cement-based products such as tile adhesives and plasters. It improves the workability and adhesion of these materials, enabling easier application and enhanced performance. HPMC also retains moisture, which is crucial for the proper curing of construction materials.

4. Personal Care Products HPMC is a common ingredient in various personal care products, including lotions, creams, and shampoos. Its emulsifying and thickening properties help stabilize these products, providing a pleasant texture and ensuring uniform distribution of active ingredients.

Safety and Regulatory Status

HPMC is generally recognized as safe for use in food and pharmaceutical applications. Organizations such as the U.S. Food and Drug Administration (FDA) and the European Food Safety Authority (EFSA) have approved HPMC for various applications, affirming its safety profile when used as directed. However, as with any additive, it is essential to adhere to recommended usage levels to avoid any adverse effects.

Conclusion

Hydroxypropyl Methyl Cellulose (HPMC) is a multifaceted polymer that plays a crucial role in various industries due to its unique chemical properties and versatility. From its applications in pharmaceuticals as a binder and controlled-release agent to its use as a thickener in the food industry and as a stabilizer in construction materials, HPMC provides solutions that enhance product performance and consumer experience. As research continues to explore new applications and formulations, HPMC's role is expected to grow, further establishing its significance in industrial and consumer markets. The ongoing assessment of its safety and regulatory status ensures that HPMC remains a reliable component in many products we use daily.